The Hering Breuer reflex, also known as the pulmonary stretch reflex, is a physiological response that plays a vital role in regulating breathing. It involves the inhibition of inspiration and the stimulation of expiration in response to the stretching of the lungs.

Discovered by the renowned physiologists Ewald Hering and Joseph Breuer in 1868, this reflex is triggered by the activation of stretch receptors located in the walls of the bronchioles and alveoli. These receptors respond to the distension of the lungs during inhalation and initiate a neural reflex that inhibits the inspiratory motor neurons and activates the expiratory motor neurons.

The Hering Breuer reflex serves several important functions in the respiratory system. It prevents overinflation of the lungs, maintaining an optimal lung volume for efficient gas exchange. Additionally, it helps modulate respiratory rate and depth, ensuring a balanced breathing pattern. Furthermore, the reflex is involved in the coordination of respiration with other bodily functions, such as phonation and swallowing.

Mechanism of the Reflex

The Hering Breuer reflex is initiated by the stretch receptors in the lungs. These receptors, known as pulmonary stretch receptors, are specialized sensory neurons that respond to changes in lung volume. When the lungs are inflated during inspiration, the pulmonary stretch receptors become activated and send signals via the vagus nerve to the respiratory center in the brainstem.

The respiratory center then processes these signals and modulates the activity of the inspiratory and expiratory motor neurons. The inhibition of inspiratory motor neurons leads to a decrease in the force of inspiration, while the activation of expiratory motor neurons causes the muscles involved in exhalation to contract.

Role in Respiratory Control

The Hering Breuer reflex plays a significant role in maintaining breathing homeostasis. It ensures the proper regulation of respiratory rate and depth, keeping the lungs functioning within a healthy range.

During normal breathing, the Hering Breuer reflex is constantly active, providing ongoing feedback to the respiratory center about the lung volume. This feedback helps maintain a breathing pattern that meets the body’s metabolic demands for oxygen and carbon dioxide removal.

Effects on Respiratory Rate

The Hering Breuer reflex has an inhibitory effect on respiratory rate. When the lungs are inflated beyond a certain volume, the reflex triggers an increase in respiratory rate, helping to prevent overinflation and maintain optimal gas exchange.

Effects on Respiratory Depth

The reflex also influences respiratory depth. During deep breathing, such as during exercise, the Hering Breuer reflex helps maintain an appropriate tidal volume by limiting lung hyperinflation. This prevents the excessive stretching of the lungs and the associated discomfort.

Clinical Significance

The Hering Breuer reflex has implications in certain clinical conditions. Abnormal functioning of the reflex can disrupt respiratory control and contribute to respiratory disorders.

Pulmonary Diseases

Dysfunction of the Hering Breuer reflex can occur in pulmonary diseases such as asthma, emphysema, and chronic obstructive pulmonary disease (COPD). In these conditions, the elastic properties of the lungs are altered, leading to either reduced or exaggerated stretch receptor activity.

Neuromuscular Disorders

Neurological disorders affecting the vagus nerve or the respiratory center can also affect the Hering Breuer reflex. This can result in coordination problems between inspiration and expiration, leading to respiratory difficulties.


The Hering Breuer reflex is a vital physiological mechanism that plays a crucial role in regulating breathing. It ensures the protection of the lungs from overinflation, maintains a balanced respiratory rate and depth, and coordinates respiration with other bodily functions. Understanding the Hering Breuer reflex is essential not only for its physiological significance but also for its relevance in respiratory medicine and the management of respiratory disorders.



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